Table 3.
Fatty acid profile of plasma total phospholipids (mg/dL) in persons with no cognitive impairment (NCI), mild cognitive impairment (MCI) or Alzheimer’s disease (AD)
| NCI (n = 10) | MCI (n = 6) | AD (n = 9) | |
|---|---|---|---|
| Palmitate (16 : 0) | 38.0 ± 9.8a* | 41.2 ± 8.7a | 26.3 ± 10.9b |
| Stearate (18 : 0) | 23.0 ± 5.1 | 22.9 ± 3.7 | 21.6 ± 8.7 |
| ΣSaturates | 68.5 ± 23.1 | 65.1 ± 11.8 | 48.6 ± 17.9 |
| Palmitoleate (16 : 1n-7) | 0.8 ± 0.2ab | 1.2 ± 0.4b | 0.6 ± 0.3a |
| Oleate (18 : 1n-9) | 13.7 ± 2.0 | 15.3 ± 2.9 | 12.1 ± 3.5 |
| Oleate isomers | 3.9 ± 1.8 | 5.3 ± 2.1 | 6.3 ± 2.9 |
| 22 : 1n-9 | 0.6 ± 1.1 | 1.2 ± 1.6 | 0.4 ± 0.3 |
| ΣMonounsaturates | 19.2 ± 3.0 | 23.0 ± 5.1 | 19.2 ± 4.7 |
| Linoleate | 23.1 ± 15.2 | 30.1 ± 5.3 | 25.8 ± 10.0 |
| Arachidonate | 16.0 ± 4.7 | 15.6 ± 3.8 | 10.6 ± 4.7 |
| Σn-6 polyunsaturates | 45.1 ± 16.4 | 52.0 ± 10.5 | 42.0 ± 12.2 |
| α-Linolenate | 0.1 ± 0.1a | 0.2 ± 0.1ab | 0.8 ± 1.5b |
| Eicosapentaenoate | 0.9 ± 0.5a | 1.1 ± 0.7a | 0.5 ± 0.2b |
| Docosapentaenoate | 1.1 ± 0.4 | 1.2 ± 0.3 | 0.9 ± 0.4 |
| Docosahexaenoate | 4.7 ± 2.0a | 4.1 ± 0.9a | 2.4 ± 1.3b |
| Σn-3 polyunsaturates | 7.2 ± 2.4 | 7.0 ± 1.7 | 5.2 ± 3.5 |
| SUM | 140 ± 31 | 147 ± 25 | 115 ± 27 |
*
Mean ± SD;
a,b
Different superscripts denote a statistically significant between groups (p ≤ 0.05; Kruskal-Wallis followed by Mann-Whitney test).