Table 1.

Anxiety-like behavior of rats with a history of voluntary exercise or sedentary conditions that were not exposed to an experimental stressor or received an acute injection of the β-carboline FG7142.

	Sedentary 0x FG5	Sedentary 1x FG	Exercise 0x FG	Exercise 1x FG
Elevated plus maze
Open arm time (s)	31.75 ± 10.33	10.85 ± 3.39ns	30.37 ± 6.83	24.81 ± 6.29ns
Closed arm time (s)	251.31 ± 12.34	276.03 ± 4.51#	248.82 ± 6.79	266.77 ± 6.72#
Open arm entries (freq)	3.70 ± 1.23	.75 ± .25#	3.60 ± .82	2.20 ± .63#
Closed arm entries (freq)	13.60 ± 2.21	5.25 ± 1.39##	17.20 ± 1.03	7.60 ± 1.65##
Shock probe defensive burying
Burying time (s)	130.59 ± 38.98	4.15 ± 2.39##	79.85 ± 30.28	37.73 ± 14.58##
Immobility time (s)	136.69 ± 63.39	334.85 ± 38.82##	181.15 ± 42.84	378.87 ± 77.34##
Probe bites (freq)	.20 ± .20	.00 ± .00	1.00 ± .62	.10 ± .10
Rearing time (s)	155.09 ± 26.10	32.08 ± 6.40##	117.83 ± 16.61	26.73 ± 7.56##
Non-shock probe returns (freq)	2.50 ± 1.36	.13 ± .13	2.90 ± 1.75	.40 ± .22
Shock reactivity (scale)	1.90 ± .10	1.88 ± .35	2.30 ± .21	2.00 ± .00
Latency to initiate probe contact (s)	64.30 ± 41.06	16.88 ± 3.86	27.30 ± 7.36	65.89 ± 33.88
Latency to initiate burying (s)	256.60 ± 108.53	684.75 ± 134.73	285.60 ± 105.21	265.56 ± 120.80
Defensive withdrawal
Distance traveled 0–5 min (m)	5.33 ± 1.28	2.41 ± .57##	5.27 ± .96	2.97 ± .86##
Distance traveled 6–10 min (m)	6.30 ± 1.38	1.14 ± .81##	6.20 ± .86	.47 ± .13##
Distance traveled 11–15 min (m)	5.19 ± 1.40	.94 ± .73##	4.98 ± .96	.97 ± .64##
Dark box time (s)	565.45 ± 78.70	807.53 ± 42.41##	585.01 ± 31.21	740.55 ± 87.46##
Dark box transitions (freq)	18.50 ± 3.81	2.63 ± 1.35##	20.40 ± 2.66	2.40 ± .82##
Latency to enter dark box (s)	20.94 ± 3.61	48.60 ± 11.87##	20.98 ± 3.50	31.76 ± 5.85##

Data are mean ± S.E.M. (n = 8–10);

^##p < .01,

^#p < .05 vs. No injection (0x FG7142);

^nsp = .09 vs. No injection.