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. 2012 Apr;91(4):599–607. doi: 10.1189/jlb.0411191

Figure 1. The suppression of LL-37-induced chemokine response by chemical inhibitors of SFKs in human blood mononuclear cells.

Figure 1.

The cells were stimulated with 20 μg/ml LL-37 for 18 h, with the inhibitors added 1 h prior to the beginning of the stimulation at indicated concentrations. (A–C) LL-37-induced CCL2/MCP1 and CXCL8/IL-8 production was suppressed by SFK inhibitors (A) SU6656 and (B) PP2, (C) but not by the negative control compounds PP3. (D) LL-37 (20 μg/ml) and SFK inhibitors (10 μM) had minimal cytotoxicity over 18 h of treatment, as indicated by WST-1 cell viability assay. Bars represent means ± sem from three to five independent experiments. *P < 0.05; **P < 0.01 using ANOVA with Dunnett's multiple comparison post-test.