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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Radiat Res. 2012 Jun 14;178(1):57–68. doi: 10.1667/rr2806.1

FIG. 5.

FIG. 5

Complete prevention of radiation dermatitis conferred by topical or systemic administration of PrC-210 prior to irradiation. Panel A: Schematic showing placement of Sprague-Dawley rats on lead plate with 2 windows. Panel B: Increasing radiation dose gave radiation dermatitis of increasing severity (Grade 1–>4) scored 13 days after irradiation. Panel C: Topical application of 370 mM PrC-210 in 50:30:20 (ethanol:propylene glycol:water) delivery vehicle to skin before irradiation completely prevented the Grade 2–3 radiation dermatitis. Panel D: A single i.p. injection of PrC-210 at −30 min before the irradiation completely prevented the Grade 2–3 radiation dermatitis. At least 3 rats were present in each of the C–F treatment groups. Panel E: Dose-dependent prevention of radiation dermatitis by topical application of PrC-210 before irradiation. With topical application of PrC-210 in an early delivery vehicle of 0:95:5 (ethanol:propylene glycol:water), dose-dependent prevention of Grade 2–3 radiation dermatitis can be seen, but much higher concentrations of PrC-210 are required. Panel F; PrC-210 dissolved at either 370 mM or 740 mM in a 50:30:20 delivery vehicle was topically-applied at the indicated times before irradiation. Severity of radiation dermatitis was scored 13 days later.