TABLE 1. Lack of Mutagenicity of PrC-210 and PrC-211 Aminothiols in Frameshift (TA98) and Point Mutation (TA100) Salmonella typhimurium Reporter Strains.
| Molecule | Concentration (μM) |
Colonies/plate (mean ± SD) |
|||
|---|---|---|---|---|---|
| Strain TA98 |
Strain TA100 |
||||
| −S9 | +S9 | −S9 | +S9 | ||
| 0 | 52 ± 11* | 59 ± 9 | 133 ± 6 | 165 ± 20 | |
| PrC-210 | |||||
| 30 | 43 ± 2 | 6 ± 10 | 121 ± 8 | 119 | |
| 100 | 51 ± 6 | 64 ± 4 | 116 ± 22 | 127 ± 8 | |
| 400 | 58 ± 14 | 55 ± 3 | 128 | 144 ± 14 | |
| 1000 | 53 ± 3 | 54 ± 6 | 101 ± 19 | 148 ± 5 | |
| 4100 | 55 ± 5 | 55 | 134 ± 20 | 115 ± 33 | |
| 7000 | 51 ± 5 | 65 ± 9 | 128 ± 11 | 149 ± 18 | |
| PrC-211 | |||||
| 30 | 50 ± 2 | 61 ± 4 | 125 | 137 | |
| 100 | 47 ± 8 | 52 ± 5 | 139 | 114 | |
| 400 | 49 ± 6 | 52 ± 9 | 93 | 135 | |
| 1000 | 54 ± 12 | 53 ± 4 | 121 | 135 | |
| 4100 | 53 ± 3 | 61 ± 6 | 130 | 148 | |
| 7000 | 58 ± 9 | 60 | 133 | 126 | |
| Aminoanthracene | 87 | >1800 | 177 | 570 ± 90 | |
| Daunomycin | 804 | ||||
*
Mean and standard deviation of at least three plates.