Group | n | Dose and route |
mg PrC-210 applied |
NEp | Cmax (ng-eq/g) | Tmax (h) | Recoverya (excreta) |
Recovery (carcass) |
Recoveryb (systemic) |
Recoveryc (skin) | Recoveryd (total) |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 3 | 370 mM 100 μCi Dermal |
16.28 | - | 257 | 4 | 6.18% | 0.52% | 6.70% | 41.54% | 49.4% |
2 | 3 | 1850 mM 100 μCi Dermal |
81.40 | 1,630 | 8 | 13.28% | 1.84% | 15.12% | 47.16% | 66.0% | |
3 | 3 | 1850 mM 100 μCi Dermal |
81.40 | 726 | 48 | 6.88% | 1.53% | 8.41% | 60.46% | 70.0% | |
4 | 3 | 370 mM 100 μCi Dermal |
16.28 | 0.22% of topically administered dose was recoverable in expired air over 48 h |
Recovery (excreta) = urine + urine wipes + feces.
Recovery (systemic) = Recovery (excreta) + Recovery (carcass).
Recovery (skin) = skin (dose site) + skin wash.
Recovery (total) = Recovery (systemic) + Recovery (skin) + cage wash + cage wipe + enclosure + nonocclusive cover.