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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Biochemistry. 2007 Oct 26;46(46):13310–13321. doi: 10.1021/bi701386f

Figure 1.

Figure 1

(a) Chemical structures of AF-adduct [N-(2′-deoxyguanosin-8-yl)-2-aminofluorene], AAF-adduct [N-(2′-deoxyguanosin-8-yl)-2-acetylaminofluorene], and FAF-adduct [N-(2′-deoxyguanosin-8-yl)-7-fluoro-2-aminofluorene]. (b) The major groove views of the central trimer segments of the B- and S-conformers of AF-modified duplex. The modified dG and the complementary dC are shown in red and green, respectively, and the AF-moiety is highlighted with grey CPK. In the B conformer, anti-[AF]dG maintains Watson-Crick hydrogen bonds, thereby placing the AF ring in the major groove. The AF moiety of the S-conformer stacks into the helix with the modified dG in the syn conformation. (c) Sequence contexts of the fully-paired and -2 deletion NarI duplexes.