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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Biochemistry. 2007 Oct 26;46(46):13310–13321. doi: 10.1021/bi701386f

Figure 9.

Figure 9

Carton representation oftranslesion synthesis of NarI-induced -2 deletion mutations. Incorporation of correct dC opposite the AF and subsequent nucleotide incorporation (e.g. dC) can lead formation of stable S- and B-conformeric slipped mutagenic intermediates (S-SMI and B-SMI, respectively). (a) NarI-dC/-2 del resulted in an exclusive formation of S-SMI. (b) In contrast, the dT/-2 del produced a complex conformational heterogeneity involving not only S- and B-SMI, but also various intermediate conformers (*). The conformational stability of SMI is strongly modulated by the nature (Watson-Crick, orientation) of the base pairs at N position (red colored)(see text).