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ALS mutation sites make multiple interactions with Kapβ2. The Kap-NLS interface (Kapβ2, pink; FUS PY-NLS, cyan) is shown: Bottom, the C-terminal portion of the PY-NLS spanning residues 523–526; Middle, the central portion of the PY-NLS spanning residues 514–522; and Top, the N-terminal portion of the PY-NLS spanning residues 507–513.
