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. 2012 Jul 9;109(30):12177–12182. doi: 10.1073/pnas.1200247109

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Fig. 6. — TrpA1-mediated excitation of ab-PDF neuron axons induces ureter contractions. Following 5 min of incubation at high temperature (31 °C), the contraction rates of explanted midguts (A) or hindguts (B) were not significantly different between w; PDF-GAL4/+;UAS-dTrpA1/+ and GAL4/+ or UAS/+ controls (for midguts, Friedman rank sum test, P = 0.004, asymptotic general independence test, P = 0.9, n = 20; for hindguts, Friedman rank sum test, P = 0.002, asymptotic general independence test, P = 0.02, pair-wise comparisons P = 0.02 compared with GAL4 control, P = 0.3 compared with UAS control, P = 0.4 between controls, n = 20). (C) The same conditions led to a significant increase in the contraction rate of ureters in w; PDF-GAL4/+;UAS-dTrpA1/+ (Friedman rank sum test, P < 0.001, asymptotic general independence test, P < 0.001, pair-wise comparisons P < 0.001 compared with GAL4 control, P < 0.001 compared with UAS control, P = 0.4 between controls, n = 20). Full genotypes are as follows: w;PDF-GAL4/+;UAS-dTrpA1/+ (PDF > dTrpA1); w;PDF-GAL4/+ (PDF-GAL4) and w;; +/UAS-dTrpA1 (UAS-dTrpA1). *P < 0.05; ***P < 0.001.