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. 2012 Jul 9;109(30):12248–12253. doi: 10.1073/pnas.1202835109

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Fig. 3. — Adiponectin haploinsufficiency results in resistance to glucocorticoid-induced feedback inhibition of hypothalamic–pituitary–adrenal axis. (A) Dexamethasone (DEX) suppression test. DEX-induced suppression of corticosterone secretion is impaired in Adipo^+/− mice (treatment F_(1,30) = 8.394, P < 0.01; genotype F_(1,30) = 14.176, P < 0.001; treatment × genotype F_(1,30) = 3.366; P = 0.077). Wild-type, n = 10 for basal and n = 9 for DEX treatment; Adipo^+/−, n = 10 for basal and n = 7 for DEX treatment. *P < 0.05 compared with basal levels. (B) Combined DEX/CRH test. Adipo^+/− mice show enhanced corticosterone response to CRH challenge (F_(1,40) = 12.303, P = 0.001). Wild-type, n = 10; Adipo^+/−, n = 11. *P < 0.05, **P < 0.01 compared with wild-type littermate controls. All data are expressed as mean ± SEM.