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Working hypothesis for the mechanism of action of GDXa. (A) The Xa-TFPI complex is the physiological inhibitor of the TF/FVIIa coagulation initiation complex. (B) Exogenous GDXa competes with FXa for binding to TFPI, preventing the formation of the FXa-TFPI-FVIIa-TF complex and restoring thrombin generation.
