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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Neurobiol Dis. 2011 Dec 7;45(2):821–828. doi: 10.1016/j.nbd.2011.11.006

Figure 2. Effects of N-type channel blockade in layer V inhibitory terminals of control and UC cortex.

Figure 2

A. Baseline mean peak amplitude of control eIPSCs decreased by approximately 50% after local perfusion of 1 μM ω-conotoxin GVIA (left). In contrast, no difference was observed in baseline peak amplitude of eIPSCs after treatment in UCs (right). Inset: Representative traces of eIPSCs recorded in control (upper traces) and UC (lower traces) layer V Pyr cells at baseline (white bar) and after 1 μM ω-conotoxin GVIA (gray bar).

B. Normalized changes in baseline peak amplitude of eIPSCs after N-channel blockade in layer V Pyr cells from control and UC. Change in peak amplitude of eIPSC after N-channel blockade is significantly greater in control than in UCs.