Table 4.
Means (± Standard Deviations) for significant vocal acoustic measure differences between treatment responders a and nonresponders defined by primary clinical outcome measure (QIDS-C).
| Response Category | N | VA Measure | Mean (± Standard Deviation) | Responder - Nonresponder | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline | Week 4 | Change | Group t-test | df | p. | |||
| Respondersa | 51 | |||||||
| Free Speech total recording time | 120.4 (± 67.0) | 94.4 (± 37.5) | -26.0 (±50.0)*** | |||||
| Free Speech total vocalization time | 68.5 (± 39.6) | 58.0 (± 23.5) | -10.5 (±31.3) * | |||||
| Free Speech number of pauses | 118.6 (± 73.5) | 98.5 (± 53.3) | -20.1 (± 59.4) * | |||||
| Free Speech total pause time | 51.9 (± 31.5) | 36.4 (± 19.4) | -15.5 (± 25.9)*** | |||||
| Free Speech pause variability | 0.69 (± 0.25) | 0.51 (± 0.15) | -0.18 (± 0.20)*** | |||||
| Automatic Speech total recording time | 30.2 (± 9.28) | 23.2 (± 7.03) | -7.00 (± 9.45)*** | |||||
| Automatic Speech total vocalization time | 15.6 (± 3.87) | 14.3 (± 3.28) | -1.26 (± 3.88) * | |||||
| Automatic Speech speaking rate | 2.27 (± 0.70) | 2.89 (± 0.85) | 0.62 (± 0.82) * | |||||
| Mean F0 frequency | 151.8 (± 36.5) | 153.3 (± 35.7) | 1.45 (± 7.25) NS | |||||
| Mean F1 frequency | 546.8 (± 67.1) | 558.2 (± 51.8) | 11.4 (± 48.9) NS | |||||
| Nonresponders | 54 | |||||||
| Free Speech total recording time | 98.0 (± 57.9) | 107.0 (± 67.7) | 8.93 (± 49.9) NS | 3.58 | 103 | .001 | ||
| Free Speech total vocalization time | 51.3 (± 27.5) | 61.6 (±36.8) | 10.2 (± 29.3) * | 3.50 | 103 | .001 | ||
| Free Speech number of pauses | 97.1 (± 58.7) | 108.2 (±79.9) | 10.3 (± 54.6) NS | 2.72 | 102 | .008 | ||
| Free Speech total pause time | 46.7 (± 34.3) | 46.3 (± 34.6) | -1.00 (± 27.7) NS | 2.75 | 102 | .007 | ||
| Free Speech pause variability | 0.70 (± 0.26) | 0.61 (± 0.20) | -0.09 (± 0.20) ** | 2.26 | 102 | .026 | ||
| Automatic Speech total recording time | 28.9 (± 7.87) | 25.2(± 7.00) | -3.68 (± 6.90) *** | 2.06 | 103 | .042 | ||
| Automatic Speech total vocalization time | 14.6 (± 3.30) | 15.9 (± 3.56) | 1.24 (± 4.38) * | 3.10 | 103 | .003 | ||
| Automatic Speech speaking rate | 2.46 (± 1.02) | 2.70 (± 0.88) | 0.24 (± 0.95) NS | -2.19 | 103 | .031 | ||
| Mean F0 frequency | 157.3 (± 33.6) | 155.7 (± 33.5) | -1.65 (± 7.95) NS | -2.09 | 103 | .040 | ||
| Mean F1 frequency | 570.5 (± 62.1) | 556.6 (± 59.9) | -14.3 (± 46.3) * | -2.76 | 103 | .007 | ||
***
p. ≤ .001
**
p. ≤ .01
*
p. ≤ .05
NS
p. > .05
a
Responder = 50% or greater reduction of depression severity on primary outcome (QIDS-C) from Baseline to Week 4