Table 2.
POMC peptide receptors expressed in tissues and cell types of the osteoarticular system
| Receptors and tissue (cell type) | In vitro cell culture system |
|---|---|
| MOR | |
| Articular OA cartilage (h) | Primary articular chondrocytes (h) |
| Fetal long bone (r) | Primary fibroblast-like synoviocytes (h) |
| Growth plate (r) | MG63 (h) |
| Endosteum (r) | |
| Periosteum (r) | |
| Synovium (nerve fibers) (h) | |
| DOR | |
| Synovium (nerve fibers) (h) | Primary fibroblast-like synoviocytes (h) |
| MC1R | |
| Articular OA cartilage (h) | MG63 (h) |
| Growth plate (chondrocytes) (m) | Primary articular chondrocytes (h) |
| HTB-94 (h) | |
| Primary osteoblasts (h) | |
| MG63 (h), SaOs2 (h) | |
| RAW264.7 (m) | |
| MC2R | |
| Bone (osteoblasts, osteocytes) (m) | Primary articular chondrocytes (h) |
| Growth plate (chondrocytes) (m) | Primary osteoblasts (h), (r) |
| MG63 (h), SaOs2 (h) | |
| Primary osteoclasts (r) | |
| RAW264.7 (m) | |
| MC3R | |
| Growth plate (chondrocytes) (m) | RCJ3.1 (r) |
| Bone marrow stromal cells (r) | |
| Resting chondrocytes (r) | |
| MG63 (h) | |
| Primary osteoclasts (r) | |
| RAW264.7 (m) | |
| MC4R | |
| Periosteum (m) | UMR106.06 (r) |
| Growth plate (chondrocytes) (m) | Primary osteoblasts (h), (r) |
| Primary articular chondrocytes (h) | |
| SaOs2 (h) | |
| Primary osteoclasts (r) | |
| RAW264.7 (m) | |
| MC5R | |
| Growth plate (chondrocytes) (m) | Primary articular chondrocytes (h) |
| MG63 (h) | |
| RAW264.7 (m) |
h, Human; m, mouse; r, rat.