Figure 4.

Kaplan–Meier overall survival curves. (a) A high expression of thioredoxin interacting protein is significantly associated with a better prognosis (P=0.037). (b) Oestrogen receptor status is an independent predictive factor (P=0.014 in this cohort). Therefore, correlations were made between redox proteins and oestrogen receptor status by grouping patients: 1=oestrogen receptor negative with low redox expression, 2=oestrogen receptor negative with high redox expression, 3=oestrogen receptor positive with low redox expression, 4=oestrogen receptor positive with high redox expression. (c) Oestrogen receptor negative cases with a low thioredoxin interacting protein expression had a considerably worse prognosis (P=0.00006) (group 1) and analysing this group against the others combined (d) was highly significant (P=0.000003).