Table 2.
Summary of responses to kisspeptin 112–121 0.24 nmol/kg, iv, × 1
| Women |
Men (n = 13) (9) | |||
|---|---|---|---|---|
| Early follicular (n = 10) | Preovulatory (n = 3) | Midluteal (n = 14) | ||
| Percentage exhibiting an LH pulse immediately after kisspeptin | 50% | 100% | 100% | 100% |
| LH pulse amplitude (mIU/ml) | ||||
| Endogenous | 1.2 ± 0.2 | 10.4 ± 2.4 | 3.0 ± 0.4 | 2.1 ± 0.3 |
| Kisspeptin-induced | 1.1 ± 0.3 | 28.6 ± 5.1a | 4.0 ± 0.8 | 5.0 ± 1.0a |
| LH pulse AUC (min/mIU · ml) | ||||
| Endogenous | 163 ± 41 | 1723 ± 578 | 285 ± 46 | 312 ± 52 |
| Kisspeptin-induced | 161 ± 83 | 4528 ± 1143a | 593 ± 58a | 684 ± 118a |
| Time from nadir to peak (min) | ||||
| Endogenous | 15.8 ± 0.8 | 19.2 ± 2.2 | 22.1 ± 2.0 | 22.8 ± 1.4 |
| Kisspeptin-induced | 22.9 ± 3.6a | 36.7 ± 3.3a | 24.3 ± 2.0 | 27.7 ± 1.7a |
| FSH on 2-h pools (mIU/ml) | ||||
| Endogenous | 5.8 ± 0.3 | 9.8 ± 1.9 | 2.7 ± 0.3 | 2.9 ± 0.4 |
| Kisspeptin-induced | 5.9 ± 0.4 | 10.7 ± 1.4 | 2.9 ± 0.4a | 3.3 ± 0.5a |
| Estradiol on 2-h pools (pg/ml) | ||||
| Endogenous | 35 ± 3 | 145 ± 36 | 117 ± 9 | ND |
| Kisspeptin-induced | 34 ± 3 | 128 ± 34 | 123 ± 9a | ND |
| Endogenous interpulse interval, A (min) | 71 ± 7 | 73 ± 9 | 213 ± 33 | 130 ± 8 |
| Interval between kisspeptin-induced pulse and previous endogenous pulse, B1 (min) | 60 ± 12 | 40 ± 15 | 155 ± 37 | 62 ± 14 |
| Interval between kisspeptin-induced pulse and next endogenous pulse, B2 (min) | 78 ± 19 | 107 ± 23 | 130 ± 19a | 141 ± 21b |
Data are shown as mean ± sem. ND, Not determined.
a
P < 0.05 compared with endogenous.
b
P < 0.05 compared with interval B1.