Table 2.
RR of thyroid cancer with benign thyroid or endocrine disorders in male White and Black U.S. veterans
| Disorder | All |
Time to thyroid cancer diagnosis |
Pc | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| <5 yr |
≥5 yr |
|||||||||
| n/PYa | RRb | 95% CI | n | RR | 95% CI | n | RR | 95% CI | ||
| Any thyroid gland disorder | 252/58.7 × 104 | 23.3 | 20.1–26.9 | 199 | 37.1 | 31.6–43.7 | 53 | 9.5 | 7.2–12.6 | <0.001 |
| Thyroid adenoma | 18/9.5 × 103 | 67.9 | 42.4–108.8 | 15 | 92.8 | 55.4–155.3 | 3 | 28.9 | 9.3–90.2 | <0.001 |
| Nontoxic nodular goiter | 145/17.1 × 103 | 77.8 | 64.5–93.1 | 117 | 141.8 | 116.3–172.8 | 28 | 25.9 | 17.9–38.0 | <0.001 |
| Simple or unspecified goiter | 45/44.8 × 103 | 41.5 | 30.7–56.1 | 31 | 63.4 | 44.2–90.9 | 14 | 23.3 | 13.7–39.7 | <0.001 |
| Thyrotoxicosis with or without goiter | 28/18.9 × 104 | 6.4 | 4.4–9.4 | 23 | 12.4 | 8.2–18.8 | 5 | 2.0 | 0.8–4.8 | <0.001 |
| Hypothyroidism | 68/29.7 × 104 | 8.8 | 6.9–11.3 | 49 | 10.7 | 8.0–14.4 | 19 | 6.0 | 3.8–9.6 | <0.001 |
| Thyroiditis | 13/21.3 × 103 | 23.9 | 13.8–41.3 | 9 | 38.4 | 19.9–74.2 | 4 | 12.9 | 4.8–34.4 | <0.001 |
| Other thyroid disorder | 17/25.3 × 103 | 25.9 | 16.0–41.9 | 13 | 39.8 | 23.0–69.0 | 4 | 12.1 | 4.5–32.4 | <0.001 |
| Multiple thyroid disorders | ||||||||||
| None | 846/52.3 × 106 | 1.0 | 1.0 | 1.0 | ||||||
| One | 174/31.2 × 104 | 30.1 | 25.5–35.5 | 148 | 58.5 | 48.9–70.0 | 26 | 7.6 | 5.2–11.3 | <0.001 |
| Two or more | 33/31.7 × 103 | 48.6 | 34.2–69.1 | 19 | 75.4 | 47.7–119.4 | 14 | 31.3 | 18.4–53.4 | 0.01 |
| Other endocrine disorders | ||||||||||
| Diabetes | 146/46.1 × 105 | 1.2 | 1.0–1.4 | 75 | 1.3 | 1.0–1.6 | 71 | 1.1 | 0.9–1.5 | 0.11 |
| Disorders of parathyroid glands | 17/60.1 × 103 | 10.7 | 6.6–17.3 | 14 | 19.6 | 11.6–33.3 | 3 | 3.4 | 1.1–10.6 | <0.001 |
PY, Person-years.
Number of thyroid cancer cases and person-years of follow-up for individuals with preexisting disorder of interest. We chose not to present the number of thyroid cancer cases and person-years of follow-up for individuals without disorder of interest because 1) the number of cases is a difference between 1053, total number of cases, and number of cases with disorder of interest presented in the table and 2) person-years at risk for individuals without specific thyroid/endocrine disorder vary little across all disorders considered and similar to person-years presented for individuals who have no thyroid/endocrine disorders.
RR adjusted for attained age, calendar time, race, time on study, and number of hospitalizations by stratification.
P likelihood ratio-based test of trend in relative risk by time to thyroid cancer diagnosis.