Fig. 1.

Trajectory of E2 across the FMP. Significant predictors for trajectory separation were race/ethnicity and BMI (see Supplemental Table 2 for modeling details). E2 levels were the average observed serum E2 levels at each time point. Time-varying age, SHBG, and cycle day of blood draw were adjusted in the model. The model accuracy diagnostics showed that the capacity of the model to separate women among the groups was good. The AvePP ranged from 0.72 to 0.81 and the OCC ranged from 6.44 to 10.98.