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. 2012 May 24;97(8):E1532–E1539. doi: 10.1210/jc.2012-1334

Fig. 1.

Fig. 1.

A, Kindred structure of the affected family. Affected members are shown as filled symbols. The arrow indicates the index case. B, Part of the sequencing chromatogram of exon 2 of the KCNJ5 gene in a normal subject (upper panel) and the patients carrying the heterozygous T-to-G transition n.G470T (lower panel). C, KCNJ5 mutations result in the depolarization of current reversal potential. Reversal potentials are plotted for wild-type (WT) Kir3.4 (KCNJ5)/Kir3.1 (KCNJ3) channels and each Kir3.4 (KCNJ5) mutant/Kir3.1 (KCNJ3). WT channels (white bar) show a negative reversal potential. Mutant channels (gray bars) show less negative reversal potentials (P < 0.05 in each case), suggesting a loss of ion selectivity. Numbers in parentheses are the number of cells recorded.