Table 2.
Over- and underexpressed proteins involved in critical cellular functions
| Function | Protein expression |
|
|---|---|---|
| Overexpressed | Underexpressed | |
| Transcription | PPAR-γ, HNF-1α, Id1, YBX1, HMG1(Y), Fra1, c-myc | NKX2–1, FOXE1, Pax8, CBX7 |
| Signaling | EGFR, CXR4, pAKt1, pERK, JAK/STAT | SOCS 1, 3, 5 |
| Mitosis | Aurora kinases, kα1 tubulin, topoisomerase-11 | TACC3 |
| Proliferation | MKI67, OEATC-1, RBBP4, SPAG9 | |
| Cell cycle | Cyclins D1, D3, E | p21, p27 |
| Apoptosis | IAPs, DJ-1, NF-κΒ, LCN2 | Bcl2, αB-crystallin |
| Adhesion | Β-catenin, ILK1, FAK | E-cadherin |
| Tumor suppressor | p53 | Rb, p16, PTEN |
[Reprinted from R. C. Smallridge and J. A. Copland: Anaplastic thyroid carcinoma: pathogenesis and emerging therapies. Clin Oncol (R Coll Radiol) 22:486–497, 2010 (6), with permission. © The Royal College of Radiologists.]