Table III.
Changes in serum TNF-α, IL-6, IL-10, NOXa, and HMGB1.
| Variable |
Time/Group |
BL |
ST |
4 h |
12 h |
|---|---|---|---|---|---|
| TNF-α (pg mL-1) | NE | 11 ± 4 | 3546 ± 872 | 853 ± 217 | 68 ± 14 |
| AVP | 16 ± 6 | 3161 ± 919 | 448 ± 113 | 63 ± 1 | |
| IL-6 (ng mL-1) | NE | ND | 13.3 ± 3.8 | 9.8 ± 2.9 | 4.2 ± 1.3 |
| AVP | ND | 15.6 ± 4.3 | 10.7 ± 3.5 | 3.7 ± 1.4 | |
| IL-10 (pg mL-1) | NE | 6 ± 2 | 134 ± 23 | 94 ± 24 | 43 ± 14 |
| AVP | 5 ± 2 | 152 ± 44 | 89± 18 | 54 ± 11 | |
| NOXa (mol L-1) | NE | 16 ± 5 | 23 ± 8 | 46 ± 7 | 49 ± 8 |
| AVP | 19 ± 5 | 22 ± 6 | 30 ± 6a | 33 ± 6a | |
| HMGB1 (μg L-1) | NE | ND | 5 ± 1 | 17 ± 4 | 28 ± 5 |
| AVP | ND | 6 ± 2 | 15 ± 3 | 19 ± 4a |
a P < 0.05 versus NE group.
AVP = arginine vasopressin; BL = baseline; ND = not detected; NE = norepinephrine; ST = shock time.