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. 2012 Jul 25;2012:578497. doi: 10.1155/2012/578497

Figure 1.

Figure 1

Body weight changes in the LT4 and test materials-treated rats. Significant (P < 0.01) decreases of the body weights were detected in LT4 control as compared with intact control from 6 days after first LT4 treatment, throughout experimental periods (arrow). However, these decreases of body weights were significantly (P < 0.01 or P < 0.05) inhibited by treatment of BR 300, 150, and 75 mg/kg or PTU 10 mg/kg from 5 days after administration (dot arrow), respectively. Values are expressed as mean ± S.D. of eight rats; BR: aqueous Bupleuri Radix extracts; LT4: levothyroxine; PTU: propylthiouracil. All BR and PTU were administered from 12 days after first LT4 treatment. All animals were fasted before first LT4 and test material treatment and sacrifice. a P < 0.01 as compared with intact control by LSD test; b P < 0.01 as compared with LT4 control by LSD test.