Table 3.
Signal detections for warfarin-, aspirin- and clopidogrel-associated haemorrhage and haematoma.
| N | PRR (χ2) | ROR (95% two-sided CI) | IC (95% two-sided CI) | EBGM (95% one-sided CI) | |
|---|---|---|---|---|---|
| Haemorrhage | |||||
| Warfarin | 1072 | 4.938* (3363.124) | 5.080* (4.779, 5.381) | 2.290* (2.202, 2.378) | 4.902* (4.659) |
| Aspirin | 209 | 2.506* (187.540) | 2.517* (2.196, 2.837) | 1.309* (1.112, 1.505) | 2.455* (2.188) |
| Clopidogrel | 541 | 3.208* (820.735) | 3.247* (2.982, 3.513) | 1.670* (1.547, 1.793) | 3.170* (2.952) |
| Haematoma | |||||
| Warfarin | 494 | 4.226* (1218.110) | 4.326* (3.955, 4.697) | 2.065* (1.936, 2.194) | 4.186* (3.881) |
| Aspirin | 118 | 2.634* (118.048) | 2.646* (2.207, 3.084) | 1.370* (1.109, 1.631) | 2.542* (2.180) |
| Clopidogrel | 254 | 2.801* (293.327) | 2.829* (2.499, 3.159) | 1.471* (1.292, 1.650) | 2.750* (2.477) |
N: the number of co-occurrences.
*: signal detected, and a signal means a drug-associated adverse event (see “Methods” for the criteria of detection).
Haemorrhage and haematoma were coded as PT10055798 and PT10018852, respectively.
PRR: the proportional reporting ratio, ROR: the reporting odds ratio, IC: the information component, EBGM: the empirical Bayes geometric mean.