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Structure-based analysis of mutant MUTYH protein by homology modelling (Site Directed Mutator): the figure shows the possible switch of the MUTYH protein folding when a single aminoacid residue is mutated in the NUDIX domain. (A) Three dimensional structure of the NUDIX domain of MUTYH protein (PDB database); (B) Protein folding of the wild-type NUDIX domain. (C) Protein switch of the NUDIX domain containing the substitution G457W.
