Table III.

Lead SNPs at pairs of loci with strong evidence of interaction (P<10⁻¹⁰) in a GWA study of T2D

SNP 1					SNP 2					Interaction p-value		Single-locus p-value
ID	Chromosome	Position	Locus	MAF	ID	Chromosome	Position	Locus	MAF	Rapid	GLM	SNP1	SNP2
rs6421008	8	135581827	ZFAT	0.05	rs7827545	8	135635749	ZFAT	0.32	1.8 × 10−14	1.6 × 10−11	5.1 × 10−1	1.8 × 10−3
rs10916293	1	224738665	OBSCN	0.33	rs9314349	8	27530121	CLU	0.38	1.5 × 10−11	2.8 × 10−11	5.7 × 10−1	9.0 × 10−1

For each SNP, the nearest gene in the locus is indicated. Rapid and GLM interaction P-values are obtained from the two stages of the IntRapid analysis. Single-locus P-values are obtained from a GLM without interaction effects.