Table 3.

Levels of fatty acids in serum as a % of total fatty acids

		% of total fatty acids†‡
Genotype	Diet	SFA§	MUFA∥	linoleic (18:2ω6)	linolenic (18:3ω3)	arachidonic (20:4ω6)	EPA (20:5ω3)	DHA (22:6ω3)	% ω3 HUFAζ
COX-1 null	oleate	20.2 ± 1.6	16.7 ± 1.9	12.8 ± 1.2	0.252 ± 0.048	41.1 ± 4.9	0.206 ± 0.011	6.61 ± 0.16	14.0 ± 1.5
	fish oil	23.3 ± 0.50	15.8 ± 0.56	13.5 ± 0.65	0.395 ± 0.022b	16.0 ± 0.78c	13.2 ± 0.028c	16.0 ± 0.32c	62.3 ± 1.3c
COX-2 null	oleate	19.0 ± 1.6	15.1 ± 0.72	12.3 ± 0.65	0.221 ± 0.020	44.9 ± 3.5	0.207 ± 0.015	6.59 ± 0.83	13.0 ± 2.3
	fish oil	24.0 ± 0.30a	15.3 ± 0.50	15.7 ± 0.93a	0.405 ± 0.019c	14.1 ± 1.0c	12.0 ± 0.34c	16.8 ± 0.50c	65.0 ± 1.6c
wild-type	oleate	17.4 ± 0.51	14.9 ± 0.59	9.90 ± 0.19	0.183 ± 0.012	50.0 ± 1.2	0.177 ± 0.028	5.79 ± 0.11	10.4 ± 0.33
	fish oil	23.7 ± 0.68b	15.0 ± 1.2	14.8 ± 1.1b	0.361 ± 0.016c	16.3 ± 0.72c	12.5 ± 0.77c	15.5 ± 1.2c	61.2 ± 0.77c

^†Values represent mean ± SEM

^‡Means that differ significantly within each column are denoted as follows: significantly different than oleate diet for mice with the same genotype at ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. No differences were detected between genotypes within the same diet

^§SFA: saturated fatty acids (12:0, 14:0, 16:0)

^∥MUFA: monounsaturated fatty acids (16:1, 18:1)

^ζThe % of highly unsaturated fatty acids (≥20 carbons and ≥3 double bonds) that are ω3