. Author manuscript; available in PMC: 2012 Aug 2.

Published in final edited form as: Nutr Cancer. 2011 Dec 9;64(1):163–172. doi: 10.1080/01635581.2012.630168

Table 4.

Enantiomeric composition of 5-, 12- and 15-HETEs in mouse colon mucosa.

Treatment		% R-enantiomer^†‡
Genotype	Diet	5-HETE	12-HETE	15-HETE
COX-1 null	oleate	59.5 ± 2.7	1.3 ± 0.2	18.0 ± 2.3^a
	fish oil	58.8 ± 5.0^a	7.3 ± 2.5^c	46.9 ± 5.7^c
COX-2 null	oleate	61.9 ± 2.4	4.5 ± 1.7	39.7 ± 5.6^b
	fish oil	67.4 ± 8.0	15.7 ± 6.9^abc	57.6 ± 6.6^c
wild-type	oleate	65.6 ± 2.7	2.0 ± 0.5	34.3 ± 3.9
	fish oil	72.2 ± 2.5	6.6 ± 1.9	54.7 ± 4.2^c

^†

Values represent mean ± SEM

^‡

Within each column, statistically significant differences (P<0.05) between means are indicated by superscripts: ^asignificantly different from wild-type mice fed the same diet, ^bsignificantly different from COX-1 null mice fed the same diet, ^csignificantly different from mice fed the oleate diet in the same genotype