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. Author manuscript; available in PMC: 2012 Aug 2.
Published in final edited form as: Circulation. 2006 Jan 24;113(3):394–404. doi: 10.1161/CIRCULATIONAHA.105.521450

Figure 8.

Figure 8

TTC (a) and MDCT (b) images and hematoxylin and eosin histopathology analysis (c–e) from myocardial samples extracted ≈2 hours after the ischemic event. Samples were taken from remote, infarcted, and border regions. Remote myocardial areas (TTC-negative) demonstrate no change to the normal canine myocardial elements, including unremarkable myocytes and blood vessels (c). The TTC-negative (infarct) region demonstrated multiple changes that were consistent with acute myocyte necrosis, including extensive contraction band necrosis without evidence of nuclear changes (arrow) and waves of neutrophils leaving small blood vessels and collecting within interstitial spaces (arrow, d). In the border-zone region, normal myocytes were separated by large waves of neutrophilic infiltrate and contraction band necrosis (e).