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Schematic representation of the AKR1B1, Akr1b3, and AKR1B10 promoters. Cis- and trans-acting factors shown to be involved in stress responsiveness are indicated. TonE, tonicity response element; AP1, activator protein-1 binding site; ARE, antioxidant response element; C/EBP, CCAAT enhancer binding protein binding site; Sp1, selective promoter factor 1 binding site.
