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CaMKIIα-hKO mice, a representative mouse model of immature dentate gyrus' (iDG), possess a perpetually immature hippocampal formation. Expression of early neuronal markers is elevated in mutant mice (calretinin shownin a, b), which display a deficit in the mature neuronal marker calbindin (c, d). Neurogenesis is substantially increased in the dentate gyrus of mutant iDG mice (e). Scale bar=100 μm. ***P<0.001.
