Figure 2.

Identification of immature dentate gyrus' (iDG) in a subset of schizophrenia/bipolar disorder (SCZ/BPD) patients. Expression of (a) calretinin, (b) calbindin and (c) PCNA ratios within the dentate gyrus (DG) of SCZ, BPD and major depressive disorder (MDD) cohorts. Calretinin was consistently overexpressed in DG neurons in SZ/BPD patients vscontrol (d2–f2; boxed areas magnified in d3–f3; DAPI d1–f1). Elevated calretinin expression is positively associated with (g) suicide death, (h) psychosis diagnosis and (i) disease duration and (j)negatively associated with age at disease onset. (i–j) SCZ = green, BPD = blue, MDD = brown. Scale bars: 1 mm (d–f1, 2); 100 μm (d–f3). P values: ^*<0.05, ^**<0.01.