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Toxicity
| Adverse event | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Nausea/vomiting | 11/10 | 9/8 | 3/1 | |
| Fatigue | 11 | 2 | 2 | |
| Constipation | 11 | 2 | ||
| Anorexia | 9 | 3 | ||
| Myalgia/bone pain | 8 | |||
| Neuropathy | 6 | |||
| Abdominal pain | 2 | 2 | ||
| Renal insufficiency | 1 | 3 | ||
| Diarrhea | 1 | 1 | ||
| Neutropenia | 1 | 2 | 1 | 2 |
| Thrombocytopenia | 2 | 1 | 1 | |
| Anemia | 5 | 6 | 4 | |
| Infection | 3 | |||
| Mucositis | 2 | |||
| Fever | 2 | 2 | ||
| Hearing loss/tinnitus | 2 | 2 | ||
| Dizziness | 1 | |||
| Headache | 3 | |||
| Hypertension | 1 | |||
| Edema | 3 | |||
| Rash | 2 | |||
| Hypomagnesemia | 4 | |||
| Hyperkalemia | 1 | 1 | ||
| Hypokalemia | 1 | 2 | ||
| Hyponatremia | 1 | |||
| Hypocalcemia | 1 |
