Table 3.
Nucleotide change | Amino acid change | Gene | Vero p7 | SY5Y p6 | HeLa p4 |
---|---|---|---|---|---|
G1098àA | Glu49àLys | E | + | ||
C1272àT | E | + | |||
A1644àG | Thr225àAla | E | + | ||
G2121àA | Glu490àLys | E | + | ||
G2324àC | Met457àlle | E | + | + | |
A6784àG | Lys125àArg | NS4A | + | +/-* | |
T7186àC | Thr125àPro | NS4B | + | ||
T8765àC | Asn390àLys | NS5 | + † |
Note:
mixture of mutant and non-mutant nucleotides
mutation detected in passage 11 of Stock A virus