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. 2012 Jul 24;7:3951–3959. doi: 10.2147/IJN.S33670

Figure 4.

Figure 4

Effects of PEO-PPO-PEO and PLGA nanoparticles incorporating kaempferol on OVCAR-3 ovarian cancer cells and immortalized IOSE397 epithelial ovarian cells at (A) 10 μM and (B) 25 μM. Ovarian cells were seeded in microplates, incubated overnight, and treated with kaempferol or its nanoparticles for 24 hours.

Notes: Viability of cells was measured using an MTS-based method. Data represent the mean ± standard error of the mean from a minimum of three independent experiments. *P < 0.05, **P < 0.01 versus kaempferol in phosphate-buffered saline solution. #P < 0.01 versus PLGA nanoparticles incorporating kaempferol in treating the same cell type.

Abbreviations: MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium; PBS, phosphate-buffered saline solution; NP, nanoparticle; PEO-PPO-PEO, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide); PLGA, poly(DL-lactic acid-co-glycolic acid).