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CuAAC reactions on the Qβ virus-like particle using an excess of 3 as a ligand. A) Reaction scheme. B) Substrate alkynes. 14 was prepared by reaction of highly purified BSA (10 mg mL−1) with two equivalents of an oxanorbornadiene electrophile, followed by size-exclusion purification. C) Size-exclusion chromatography of the products.
