Fig. 2.

Tissue factor (TF)-VIIa activity and tissue factor pathway inhibitor (TFPI) levels in plasma. Panel A shows the TF-VIIa activity in the plasma of controls and of the patient, measured using a chromogenic assay. Whereas treatment of the patient’s plasma with a control IgG had no effect on the TF-VII activity, an anti-TF monoclonal antibody markedly decreased it. The addition of anti-TF antibody to normal plasma had no significant effect on its TF-VIIa activity. Panel B shows the plasma levels of TF pathway inhibitor antigen in controls and in the patient. The horizontal bar indicates the mean value.