Figure 8.

Schematic of mechanisms at the neurovascular unit which contribute to LPS-induced decreases in Aβ efflux by the BBB. Decreased efflux at the brain endothelial cell (EC) is due to functional impairment of LRP-1 (a) that may involve (b) or not involve (c) Pgp (b). Impairment of Pgp could also result in increased vascular uptake of Aβ from the periphery (d). Increased internalization of Aβ in the pericyte (PC) through upregulation of LRP-1 may also contribute to Aβ partitioning in the brain vasculature (e). Dashed line across endothelial cell indicates unknown subcellular routes in the translocation of Aβ.