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. 2012 Aug 2;8(8):e1002842. doi: 10.1371/journal.ppat.1002842

Table 1. Summary of published CPAF substrates.

Reported Substrate Reported Proteolysis References Proteolysis when CPAF is inhibited during cell processing (this study)
Host Proteins
Golgin-84 Cleavage [16][17] No cleavage
Puma Degradation [18][19], [36], [48] No degradation
Bim Degradation [18][19], [36], [48] No degradation
Bik Degradation [19], [36] No degradation
Keratin-8 Cleavage [20], [30] No cleavage
Keratin-18 Partial Cleavage [20] No cleavage
Vimentin Partial Cleavage [20] No cleavage
p65/RelA Cleavage [22], [38] No cleavage
Cyclin B1 Cleavage [18], [31] No cleavage
Nectin-1 Degradation [23], [49] No degradation
RFX5 Degradation [15], [21] No degradation
USF-1 Degradation [15], [50] Not tested
CD1d Degradation [51] Not tested
PARP Partial Cleavage [18], [52] Not tested
HMGB1 Cleavage [52] Not tested
HIF-1 Degradation [53] Not tested
Chlamydial proteins
CPAF Cleavage [12], [32] Cleavage
CT005 Degradation [37] Not tested
IncD (CT115) Degradation [37] Not tested
IncE (CT116) Cleavage [37] Not tested
IncC (CT233) Degradation [37] Not tested
CT288 Degradation [37] Not tested
CT694 Degradation [37] Not tested
CT813 Cleavage [37] Not tested
TARP (CT456) Degradation [37] Not tested