Table 1. Summary of published CPAF substrates.
Reported Substrate | Reported Proteolysis | References | Proteolysis when CPAF is inhibited during cell processing (this study) |
Host Proteins | |||
Golgin-84 | Cleavage | [16]–[17] | No cleavage |
Puma | Degradation | [18]–[19], [36], [48] | No degradation |
Bim | Degradation | [18]–[19], [36], [48] | No degradation |
Bik | Degradation | [19], [36] | No degradation |
Keratin-8 | Cleavage | [20], [30] | No cleavage |
Keratin-18 | Partial Cleavage | [20] | No cleavage |
Vimentin | Partial Cleavage | [20] | No cleavage |
p65/RelA | Cleavage | [22], [38] | No cleavage |
Cyclin B1 | Cleavage | [18], [31] | No cleavage |
Nectin-1 | Degradation | [23], [49] | No degradation |
RFX5 | Degradation | [15], [21] | No degradation |
USF-1 | Degradation | [15], [50] | Not tested |
CD1d | Degradation | [51] | Not tested |
PARP | Partial Cleavage | [18], [52] | Not tested |
HMGB1 | Cleavage | [52] | Not tested |
HIF-1 | Degradation | [53] | Not tested |
Chlamydial proteins | |||
CPAF | Cleavage | [12], [32] | Cleavage |
CT005 | Degradation | [37] | Not tested |
IncD (CT115) | Degradation | [37] | Not tested |
IncE (CT116) | Cleavage | [37] | Not tested |
IncC (CT233) | Degradation | [37] | Not tested |
CT288 | Degradation | [37] | Not tested |
CT694 | Degradation | [37] | Not tested |
CT813 | Cleavage | [37] | Not tested |
TARP (CT456) | Degradation | [37] | Not tested |