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. 2012 Aug 2;7(8):e41523. doi: 10.1371/journal.pone.0041523

Figure 5. miR-7 inhibits breast cancer cell tumorigenesis in vitro.

Figure 5

(A) miR-7 decreases MDA-MB-435s and MDA-MB-231 cell proliferation in vitro and inhibition of endogenous miR-7 expression promotes HBL-100 cell monolayer proliferation. (B) miR-7 inhibits MDA-MB-435s anchorage independent growth in soft agar. (C) Inhibition of miR-7 promotes HBL-100 cell anchorage independent growth in soft agar. (D) Morphology of MDA-MB-435s and MDA-MB-231 cells cultured in three-dimensional Matrigel after transfection with mature miR-7 or the control miRNA.