Table 3.
Expression of MDR-related gene mRNA species in nomegestrol-pretreated MCF7/ADR cells
| Comparison | Duration of treatment (days) | MDR1 | GSTπ | MRP | TopoIIα |
| MA | 0 | 1.7 ± 0.61 | 2.0 ± 0.82 | 0.9 ± 0.30 | 0.4 ± 0.10 |
| 2 | 0.5 ± 0.22* | 0.5 ± 0.24** | 0.7 ± 0.19 | 0.4 ± 0.15 | |
| 3 | 0.1 ± 0.04** | 0.5 ± 0.15** | 0.7 ± 0.34 | 0.5 ± 0.21 | |
| 5 | 0.5 ± 0.21* | 0.7 ± 0.30* | 0.8 ± 0.17 | 0.5 ± 0.18 | |
| 10 | 1.5 ± 0.60 | 0.9 ± 0.80* | 0.7 ± 0.25 | 0.4 ± 0.09 | |
| MW | 0 | - | - | 0.6 ± 0.24 | 0.8 ± 0.31 |
| 2 | - | - | 0.7 ± 0.27 | 0.8 ± 0.38 | |
| 3 | - | - | 0.5 ± 0.30 | 0.7 ± 0.19 | |
| 5 | - | - | 0.7 ± 0.31 | 0.7 ± 0.32 | |
| 10 | - | - | 0.6 ± 0.18 | 0.7 ± 0.26 |
Values are ratios of β-actin to MDR-related genes: MA, MCF7/ADR; MW, MCF7/WT. Statistical significance compared with control: *, P <0.05; **, P < 0.01. Data are means ± standard deviation from three experiments. GSTπ, glutathione S-transferase Pi; MDR, multidrug resistance; MRP, MDR-related protein; TopoIIα, topoisomerase IIα.