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. 2012 Aug 2;7(8):e42404. doi: 10.1371/journal.pone.0042404

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© 2012 Prole, Taylor

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Predicted topology of Ca_v channels, with the voltage sensor TMD4 regions of each domain highlighted in red; (B) Multiple sequence alignment of the putative voltage sensor TMD4 regions from each domain of human Ca_v1.2 and fungal Ca_v channel homologues. The total number of basic arginine and lysine residues present in all four putative voltage sensor TMD4 regions is indicated.