Table 2.
Clinical assessment of the reactivity of HMPEI-coated materials compared to the uncoated parent materials placed in different ocular locations in the New Zealand white rabbit in vivo. The number in each group equals n. Graded on a score from 0 (normal) to 4 (severe) with a cumulative score shown in the last row.
| Intrastromal PMMA 3-mm disc | Intrastromal titanium 3-mm disc | Intrastromal-anterior chamber KPro-FP | B-KPro-corneal autograft | |||||
|---|---|---|---|---|---|---|---|---|
| HMPEI-PMMA n = 4 | PMMA n = 4 | HMPEI-Ti n = 4 | Ti n = 4 | HMPEI-PMMA n = 3 | PMMA n = 4 | HMPEI-PMMA n = 1 | PMMA n = 2 | |
| Corneal edema | 0 | 2 | 0 | 0 | 1 | 3 | 1 | 2 |
| Corneal haze/infiltrate | 1 | 3 | 0 | 0 | 1 | 2 | 1 | 3 |
| Corneal neovascularization | 1 | 3 | 0 | 0 | 1 | 4 | 3 | 4 |
| Conjunctival chemosis | 1 | 2 | 1 | 1 | 3 | 3 | 1 | 2 |
| Conjunctival discharge | 0 | 1 | 0 | 0 | 1 | 2 | 1 | 3 |
| Epithelial defects | - | - | - | - | 1 | 4 | - | - |
| Iritis / pupil size | - | - | - | - | 1 / 6 mm | 4 / 10 mm | - | - |
| Anterior chamber flare/cells | - | - | - | - | 1 | 2 | - | - |
| Retroprosthetic membrane | - | - | - | - | 2 | 3 | 1 | 1 |
| Cataract formation | - | - | - | - | 1 | 0 | - | - |
| Total score | 3 | 8 | 1 | 1 | 13 | 27 | 8 | 14 |