Table 1.
Baseline Characteristics of the Study Population.*
| Variable | Positive for Both M. perstans and W. bancrofti | Positive for M. perstans and Negative for W. bancrofti | Total Population | |||
|---|---|---|---|---|---|---|
| No Treatment (N=67) | Doxycycline (N=64) | No Treatment (N=43) | Doxycycline (N=42) | No Treatment (N=110) | Doxycycline (N=106) | |
| Sex (no.) | ||||||
|
| ||||||
| Male | 37 | 33 | 27 | 26 | 64 | 59 |
|
| ||||||
| Female | 30 | 31 | 16 | 16 | 46 | 47 |
|
| ||||||
| Age (yr) | ||||||
|
| ||||||
| Median | 46 | 46 | 45 | 45 | 46 | 45 |
|
| ||||||
| Range | 14–65 | 14–65 | 15–64 | 15–65 | 14–65 | 14–65 |
|
| ||||||
| Mansonella perstans (microfilariae/ml) | ||||||
|
| ||||||
| Geometric mean | 307 | 335 | 275 | 301 | 321 | 294 |
|
| ||||||
| Range | 17–19733 | 17–8313 | 17–3519 | 17–5712 | 17–19733 | 17–8313 |
|
| ||||||
| Wuchereria bancrofti (microfilariae/ml) | ||||||
|
| ||||||
| Geometric mean | 5.8 | 5.1 | NA | NA | NA | NA |
|
| ||||||
| Range | 0–6100 | 0–8684 | NA | NA | NA | NA |
|
| ||||||
| Circulating antigen of W. bancrofti (U/ml)† | ||||||
|
| ||||||
| Geometric mean | 1311 | 1986 | NA | NA | NA | NA |
|
| ||||||
| Range | 133–61,299 | 155–146,305 | NA | NA | NA | NA |
|
| ||||||
| Positive for worm nests (no./total no.)‡ | 11/33 | 13/30 | NA | NA | NA | NA |
*
NA denotes not applicable.
†
Subjects with undetectable or indeterminate levels of circulating antigen as assessed by enzyme-linked immunosorbent assay have been excluded.
‡
Ultrasonography to detect the presence of worm nests in scrotal lymphatic vessels was performed only in men who were infected with W. bancrofti. Four men in the no-treatment group and three in the doxycycline group did not undergo ultrasonography at baseline.