Table 1.
Baseline demographics and clinical characteristics.
| Variable | Treatment | ||||||
|---|---|---|---|---|---|---|---|
| Overall n=116 |
Placebo n=58 |
N-Acetylcysteine n=58 |
p-value | ||||
| Demographics | Mean | SD | Mean | SD | Mean | SD | |
| Age (years) | 18.9 | 1.5 | 18.8 | 1.5 | 18.9 | 1.5 | 0.676 |
| Weight (kg) | 69.8 | 13.9 | 68.4 | 12.0 | 71.2 | 15.7 | 0.312 |
| Heart rate (beats per minute) | 66.6 | 11.4 | 66.6 | 12.0 | 66.7 | 11.0 | 0.936 |
| n | % | n | % | n | % | ||
| Age < 18 yrs | 20 | 17.2 | 10 | 17.2 | 10 | 17.2 | 1.00 |
| Gender, male | 84 | 73.0 | 45 | 77.6 | 39 | 68.4 | 0.286 |
| Race, white | 96 | 83.5 | 51 | 87.9 | 45 | 79.0 | 0.195 |
| Enrolled in school | 85 | 73.9 | 42 | 72.4 | 43 | 75.4 | 0.712 |
| Smoke cigarettes | 65 | 57.0 | 32 | 55.2 | 33 | 58.9 | 0.686 |
| Cannabis Use Characteristics | Mean | SD | Mean | SD | Mean | SD | |
| Years of cannabis use | 4.2 | 1.8 | 4.3 | 2.0 | 4.1 | 1.7 | 0.715 |
| Number of prior cannabis quit attempts | 3.3 | 9.8 | 2.7 | 3.6 | 3.9 | 13.5 | 0.516 |
| Days using cannabis in past 30 days | 22.6 | 7.2 | 22.1 | 7.3 | 23.1 | 7.2 | 0.455 |
| % of Days using cannabis in past 30 days | 75.3 | 24.1 | 73.6 | 24.4 | 77.0 | 23.9 | 0.455 |
| Days since last cannabis use | 2.2 | 3.7 | 2.3 | 3.7 | 2.1 | 3.7 | 0.546 |
| n | % | n | % | n | % | ||
| Positive urine cannabinoid test at baseline | 105 | 90.5 | 52 | 89.7 | 53 | 91.4 | 0.751 |
| Psychiatric Comorbidity | n | % | n | % | n | % | |
| Attention-Deficit/Hyperactivity Disorder | 6 | 5.2 | 4 | 6.9 | 2 | 3.5 | 0.679 |
| Conduct/Oppositional Defiant Disorder | 7 | 6.0 | 5 | 8.6 | 2 | 3.5 | 0.439 |
| Major Depressive Disorder | 9 | 7.8 | 7 | 12.1 | 2 | 3.5 | 0.162 |
| Anxiety Disorder | 9 | 7.8 | 6 | 10.3 | 3 | 5.2 | 0.490 |
| Any Psychiatric Comorbidity | 16 | 13.8 | 11 | 18.9 | 5 | 8.6 | 0.177 |