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. 2012 Jun 14;287(32):26576–26585. doi: 10.1074/jbc.M112.372813

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Conformations of CYP2A13 and possible entry/exit scheme. CYP2A13 was observed in four different conformations: closed with ligand (CYP2A13 NNK P1), intermediate (CYP2A13 NNK P1, molecule G), open to the surface (CYP2A13 NNK P1, molecule H), and closed with two NNK ligands (CYP2A13 with NNK I4222). Solid black arrows between structures suggest a continuum that would facilitate ligand entry/exit from the CYP2A13 active site. The dashed arrow represents one possible route to the CYP2A13 structure with two ligands. Red arrows highlight differences between structures. The single thick black arrow highlights the lobe of the channel connecting to the protein surface.