TABLE 1.
Minimal inhibitory concentrations of B2088 and its analogous variants against Gram-negative ATCC strains
| Peptides | Sequences | Activity (minimal inhibitory concentration)a |
|
|---|---|---|---|
| P. aeruginosa ATCC27853 | Escherichia coli ATCC 25922 | ||
| μm | |||
| V2 monomer | RGRKVVRRKK | >39 | 39 |
| B2088 (V2 dimer) | (RGRKVVRR)2KK | 2.75 | 2.75 |
| Linear V2 dimer | RGRKVVRRKKRRVVKRGR | 10.91 | 10.92 |
| Truncated V2 dimer | (KVVRR)2KK | >32.22 | 16.11 |
| V3 dimer | (RGRKVVVRR)2KK | 2.51 | 2.51 |
| V2-1A dimer | (RGRKVVRR)2KA | 5.60 | 5.60 |
| V2-1D dimer | (RGRKVVRR)2KD | 5.49 | 5.49 |
| V2-1K-amide dimer | (RGRKVVRR)2KK-NH2 | 5.46 | 5.46 |
| L2 dimer | (RGRKLLRR)2KK | 2.66 | 5.33 |
a Measurement has experiment error within 30%.