FIGURE 1.
Schematic illustration of HIV-1 gp41 functional regions and NHR- or CHR-derived peptide sequences. Shown are the residue numbers of each region corresponding to their positions in gp160 of HIV-1HXB2. FP, fusion peptide; TM, transmembrane domain; TR, tryptophan-rich domain; CP, cytoplasmic domain. The residues corresponding to the NHR pocket region are marked in magenta; the residues for the PBD are marked in yellow; the critical motif adjacent to the N-terminal of PBD is marked in red; the hot spot GIV motif for drug resistance on NHR is marked in green.