TABLE 2.
Sensitivity of naturally occurring and induced HIV-1 variants to fusion inhibitors
| HIV-1 variant | CP32M |
T20 |
||
|---|---|---|---|---|
| IC50 | -Fold change | IC50 | -Fold change | |
| nm | nm | |||
| NL4–3 wt | 0.88 ± 0.16 | 1.00 | 41.97 ± 15.95 | 1.00 |
| Natural mutation | ||||
| L33V | 1.31 ± 0.15 | 1.49 | 665.40 ± 303.49 | 15.85 |
| L34M | 2.23 ± 0.26 | 2.53 | >750 | >17.87 |
| S35F | 2.21 ± 0.47 | 2.51 | 245.90 ± 5.52 | 5.86 |
| Q39R | 1.11 ± 0.11 | 1.26 | 18.45 ± 5.93 | 0.44 |
| L54M | 2.50 ± 0.16 | 2.84 | >750 | >17.87 |
| Q56K | 3.17 ± 0.08 | 3.60 | 84.57 ± 13.53 | 2.02 |
| T20-resistant | ||||
| L33S | 1.92 ± 0.31 | 2.18 | >750 | >17.87 |
| I37Q/V38Q | 1.17 ± 0.10 | 1.33 | >750 | >17.87 |
| I37Q/V38M | 1.64 ± 0.16 | 1.86 | >750 | >17.87 |
| I37V/V38T | 1.48 ± 0.17 | 1.69 | >750 | >17.87 |