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. 2012 Jun 13;287(32):26630–26646. doi: 10.1074/jbc.M112.341255

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Role of TNFα in liver injury in malaria-infected mice. A, measurement of TNFα in serum of malaria-infected mice on day 0, 4, and 8 postinfection. B, assay of MPO activity in liver of infected mice treated with normal hamster serum or anti-TNFα antibody from day 3 to 7 postinfection. C, measurement of caspase-3 activity in malaria-infected mice treated with normal hamster serum or anti-TNFα antibody. D, measurement of bilirubin in malaria-infected mice treated with normal hamster serum or anti-TNFα antibody. Malaria-infected mice on day 0 is considered as control. The details of the methodology are described under “Experimental Procedures.” Data are presented as mean ± S.E. (**, p < 0.01 versus control; ##, p < 0.01 versus infected mice on day 0 treated with normal hamster serum; #, p < 0.01 versus infected mice on day 8 treated with normal hamster serum, n = 6).